The following videos are paid content from my Medical Biochemistry for USMLE Step 1 Exam video course. Only a select few of the videos are available for free as part of the free trial of the course. The free YouTube snippet links below give you a sneak peek at some of the videos, but to watch the rest of the free sample videos, you must sign up for a free trial. If, after taking a look at the free trial videos, you'd like to purchase full access to the course, you can do so. Click here to visit the course page.
Acids and Bases
- Terms, Definitions, and the Henderson-Hasselbalch Equation
- Which Form Predominates? Protonated or Deprotonated?
- Common Acid/Base Functional Groups
- The H2CO3/HCO3- Buffer System & Hyperventilation / Hypoventilation
Amino Acids
- Intro to Structure, Function, Importance
- Nonpolar / Hydrophobic Amino Acids
- Polar / Hydrophilic Amino Acids
- A Brief Explanation of Isoelectric pH (pI)
- Peptides, Polypeptides, Peptide Bonds
- Important Amino Acid Modifications in Proteins [ free YouTube snippet | full free sample video ]
Proteins / Protein Structure
- Intro and Importance
- Levels of Protein Structure
- Primary (1°) Structure
- Secondary (2°) Structure
- Supersecondary Structures and Motifs
- Tertiary (3°) Structure
- Quaternary (4°) Structure
- Denaturation
- Clinical Correlate: Prions [ free YouTube snippet | full free sample video ]
Myoglobin, Hemoglobin, and Hemoglobinopathies
- Myoglobin (Mb) and Hemoglobin (Hb) - Compare and Contrast
- Allosteric Regulation of Hemoglobin, Factors Affecting O2 Binding Hb, The Bohr Effect
- Carbon Monoxide Poisoning
- How High Altitude Affects Hemoglobin and its Binding Curve
- Other / Minor Hemoglobins (HbA2, HbA1C, HbF)
- Hemoglobinopathies - Introduction
- Sickle Cell Disease (HbS) -- [Qualitative Hemoglobinopathy]
- Hemoglobin C Disease (HbC) -- [Qualitative Hemoglobinopathy]
- Hemoglobin SC Disease (HbSC) -- [Qualitative Hemoglobinopathy]
- Methemoglobinemia (MetHb) -- [Qualitative Hemoglobinopathy] [ free YouTube snippet | full free sample video ]
- α-Thalassemia -- [Quantitative Hemoglobinopathy]
- β-Thalassemia -- [Quantitative Hemoglobinopathy]
Collagen and Collagen Diseases/Disorders
- Introduction / Types of Collagen [ free YouTube snippet | full free sample video ]
- Structure of Collagen [ free YouTube snippet | full free sample video ]
- Synthesis / Assembly of Collagen
- Ehlers-Danlos Syndrome (EDS)
- Osteogenesis Imperfecta (OI) / "Brittle Bone Disease"
- Alport Syndrome
- Goodpasture Syndrome (GPS)
- Menkes Disease / Menkes Syndrome (MNK)
- Scurvy
Enzymes
- The Basics
- Six Types / Classes of Enzymes [ free YouTube snippet | full free sample video ]
- Cofactors, Coenzymes, and Prosthetic Groups
- Enzyme Kinetics and the Michaelis-Menten Model
- The Lineweaver-Burk Plot / Double Reciprocal Plot
- Competitive Inhibitors
- Some Drugs that are Competitive Inhibitors
- Noncompetitive Inhibitors
- Some Drugs that are Noncompetitive Inhibitors
- Irreversible Inhibitors and Drug Examples
- Isozymes and their Use in Clinical Diagnosis
Enzyme Regulation
- Characteristics of Regulated Enzymes - How to Know if an Enzyme is Regulated
- Location / Compartmentation / Compartmentalization
- Regulation of Gene Expression
- Allosteric Regulation
- Covalent Modification - Reversible
- Covalent Modification - Irreversible
Carbohydrates
- Introduction / Basics
- Monosaccharides
- Monosaccharides (Printable PDF)
- Disaccharides
- Disaccharides (Printable PDF)
- Polysaccharides
- Polysaccharides (Printable PDF)
- Digestion and Absorption
- Carbohydrate Derivatives [ free YouTube snippet | full free sample video ]
Biochemist's Toolbox - WATCH THIS BEFORE WATCHING VIDEOS ON METABOLISM
- Biochemist's Toolbox: Redox, Metabolism, and Reaction Coupling
Glycolysis
- Intro / Overview
- The 10 Steps
- Interface with Other Pathways and Molecules
- Hexokinase vs Glucokinase [ free YouTube snippet | full free sample video ]
- Regulation
- Catabolic Fates of Pyruvate: Fermentation - Lactate and Alcohol
- Clinical Correlate: Pyruvate Kinase Deficiency (PKD)
- Clinical Correlate: Arsenic Poisoning
Gluconeogenesis (GNG)
- Intro [ free YouTube snippet | full free sample video ]
- The 11 Steps [Overview]
- The 11 Steps [Detailed Visuals]
- Interface with Other Pathways and Molecules
- Regulation
Glycogen
- Structure and Function
- Glycogen Synthesis (Glycogenesis) [ free YouTube snippet | full free sample video ]
- Glycogen Breakdown (Glycogenolysis)
- Regulation of Glycogen Metabolism
- Signal Transduction for Regulation of Glycogen Metabolism [Overview]
- Overview of Glycogen Metabolism / Interface with Other Pathways and Molecules
Glycogen Storage Diseases (GSDs)
- Intro / Overview [ free YouTube snippet | full free sample video ]
- von Gierke's Disease [Type I GSD] [ free YouTube snippet | full free sample video ]
- Pompe's Disease [Type II GSD]
- Cori's Disease [Type III GSD]
- Andersen's Disease [Type IV GSD]
- McArdle's Disease [Type V GSD]
- Hers' Disease [Type VI GSD]
- Tarui's Disease [Type VII GSD]
Galactose and Fructose
- Intro
- Galactose Metabolism [ free YouTube snippet | full free sample video ]
- Galactosemia
- Lactose Synthesis
- Fructose Metabolism
- Disorders of Fructose Metabolism
- Sorbitol and Hyperglycemia
Pentose Phosphate Pathway (PPP)
- Intro / Overview
- Reactions of the Pathway (Oxidative Phase and Non-Oxidative Phase) [ free YouTube snippet | full free sample video ]
- Regulation [Overview]
- NADPH and Glutathione as Anti-Oxidants
- G6PDH Deficiency and Hemolytic Anemia
Proteoglycans, Glycosaminoglycans (GAGs), and Glycoproteins
- Intro [ free YouTube snippet | full free sample video ]
- Glycosaminoglycans (GAGs): Structure and Function - Intro [ free YouTube snippet | full free sample video ]
- Glycosaminoglycans (GAGs): Structure and Function: 6 Classes of GAGs
- Proteoglycans: Structure and Function
- Glycosaminoglycans (GAGs): Degradation and Mucopolysaccharidoses - Intro
- Glycosaminoglycans (GAGs): Degradation of Heparan Sulfate
- Glycosaminoglycans (GAGs): Degradation of Dermatan Sulfate
- Glycosaminoglycans (GAGs): Degradation of Keratan Sulfate
- Mucopolysaccharidoses: Hurler Syndrome [Lysosomal Storage Disease]
- Mucopolysaccharidoses: Hunter Syndrome [Lysosomal Storage Disease]
- Glycoproteins: Structure and Function
- Glycoproteins: Synthesis - Overview
- Glycoproteins: Synthesis - Targeting Enzymes for Lysosomes
- Glycoproteins: Inclusion Cell (I Cell) Disease [Lysosomal Storage Disease]
The Pyruvate Dehydrogenase (PDH) Complex and TCA / Krebs / Citric Acid Cycle
- Intro and PDH Complex
- PDH Complex: Details [ free YouTube snippet | full free sample video ]
- PDH Complex: Regulation
- PDH Complex Clinical Correlate: Pyruvate Dehydrogenase Complex Deficiency (PDCD)
- PDH Complex Clinical Correlate: Arsenic Poisoning
- TCA / Krebs / Citric Acid Cycle: Reactions of the Pathway - 8 Steps
- TCA / Krebs / Citric Acid Cycle: Regulation
- TCA / Krebs / Citric Acid Cycle: Interface with Other Pathways and Molecules
Electron Transport Chain (ETC) and Oxidative Phosphorylation (OxPhos)
- Intro / Overview
- Reduction Potentials
- The Complexes of the ETC - [Overview]
- The Complexes of the ETC - [Details]
- Oxidative Phosphorylation, Chemiosmosis, ATP Synthase
- ETC Inhibitors and Uncouplers
- How Much ATP do we NET per Glucose? [Energy Calculation]
- NADH Shuttle Mechanisms (Malate-Aspartate and Glycerol-Phosphate) - [Overview]
- Malate-Aspartate Shuttle - [Details]
- Glycerol-Phosphate Shuttle - [Details]
- Hereditary Mitochondrial Diseases [ free YouTube snippet | full free sample video ]